When a patient's hemoglobin (Hb) and hematocrit (Hct) are not out of range, it is sometimes difficult for them to convince a gatekeeper that they need additional tests to rule out an iron problem. When I suspect an iron deficiency in this type of patient, I'll recommend an iron trial. The test is positive if supplemental iron makes the patient feel better. Please note: I do not recommend iron just because a patient is tired. They must have other signs and symptoms [see Part 3 (Feb. 12 issue) for details],and they must have a supportive history including regular iron losses with inadequate iron replacement.